The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology-perhaps the most extraordinary and consequential medical story of our time. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders. For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition-hallmarks of modern life-and even by excessive hygiene.

It has been honed by evolution over millennia to face an almost infinite array of threats. Its legion of microscopic foot soldiers-from T cells to “natural killers”-patrols our body, linked by a nearly instantaneous communications grid. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Two women with autoimmunity discover their own bodies have turned against them. Explicates for the lay reader the intricate biology of our immune system.' -JEROME GROOPMAN, New York Review of BooksA terminal cancer patient rises from the grave.

I highly recommend this extraordinary book.” -DOUGLAS PRESTON“Vividly told. Magnificently reported and soulfully crafted, An Elegant Defense is an epic, first-of-its-kind exploration of the human immune system and the secrets of health, by the Pulitzer Prize–winning New York Times journalist“One of those rare nonfiction books that transcends the genre. .

Book an elegant defense